Spicing up endogenous neural stem cells: aromatic-turmerone offers new possibilities for tackling neurodegeneration

There is a growing interest in the therapeutic utility of compounds derived from Curcuma longa, an herb of the Zingiberaceae family that has been part of traditional medicine for centuries. Recent reports suggest that bioactive compounds isolated from the rhizome of these plants can address two key aspects of brain injury following stroke that must be dealt with for functional recovery to occur: the moderation of neuroinflammation, and the mobilization of endogenous stem cells resident in the nervous system. Defining their mechanism of action remains a question, but emerging evidence may point towards one shared with more classic modulators of neural stem cell proliferation and survival

The serial interaction of stress and syncope

Many languages respect the generalization that some or all unstressed vowels are deleted. This generalization proves elusive in classic Optimality Theory, however. The source of the problem is classic OT’s parallel evaluation, which requires that the effects of stress assignment and syncope be optimized together. This article argues for a version of OT called Harmonic Serialism, in which the effects of stress assignment and syncope can and must be evaluated sequentially. The results are potentially applicable to other domains where process interaction is best understood in derivational terms